Google scholar | PubMed | Last update: March 2026
2026
Van der Zwet G, Bor Z, Bos R, van Dorp R, Pape LM, van der Zwet LCA, van Dijk EHC, van de Stadt H, McGlashan EM, Michel SH, Kervezee L* (2026): Sex and age modulate the relationship between melanopsin-dependent light sensitivity and chronotype across the lifespan. SLEEP: in press. doi: 10.1093/sleep/zsag057 *Corresponding author
Hiemstra FW, Bustos González L, Engelhardt LJ, Hancke L, Pilz LK, Adler AI, Dashti HS, Drouot X, Kitchen GB, Knauert MP, Kramer A, Lipton JO, Luetz A, Maas MB, Pajor NM, Parthasarathy S, Spies C, van Westerloo DJ, Felten M, Klerman EB, Ray DW, Ruben MD, Roenneberg T, and Kervezee L* (2026): Challenges and Recommendations for Integrating Circadian Medicine in Critical Care: A Roadmap. CHEST in press doi: 10.1016/j.chest.2025.12.010 *Corresponding author
Kastelein A, Kervezee L, Mink van der Molen DR, Evers DJ, van der Pol CC, Doeksen A, Chavannes NH, Gelderblom H, Neefjes J, Verkooijen HM, May AM (2026): The trajectory of fatigue over time in breast cancer patients treated with chemotherapy: exploring the effect of anthracycline-based chemotherapy. The Breast Feb:85:104700. doi: 10.1016/j.breast.2026.104700
2025
Kervezee L, Romijn M, van de Weijer KNG, Chen B, Burchell GL, Tollenaar M, Tamayo-Ortiz M, Philbrook L, de Weerth C, Cao Y, Rotteveel J, Eiden R, Azar R, Bush N, Chis A, Kmita G, Clearfield M, Beijers R, Gröschl M, Wudy SA, Kalsbeek A, Mörelius E & Finken MJJ (2025): Development of 24-hour rhythms in cortisol secretion across infancy: a systematic review and meta-analysis of individual participant data. The Journal of Clinical Endocrinology & Metabolism doi: 10.1210/clinem/dgae590
Spitschan M, Kervezee L, Stefani O, Gordijn M, Veitch JA, Lok R & Ladenburg Light and Health Consortium (2025): Evidence-based public health messaging on the non-visual effects of ocular light exposure: A modified Delphi expert consensus. BMJ Public Health. In press.Preprint available: doi: 10.1101/2025.05.07.25327160v1
Hiemstra FW, van Gent MF, de Jonge E, van Westerloo DJ*, Kervezee L* (2025): Effect of cyclic daytime versus continuous enteral nutrition on circadian rhythms in critical illness (CIRCLES): Study protocol for a randomized controlled trial. Contemp Clin Trials 154:107927. doi: 10.1016/j.cct.2025.107927 *Shared corresponding authors
Kastelein A, Mols F, Kervezee L, Chavannes NH, Gelderblom H, Neefjes J, Hinnen C (2025): The Impact of Chemotherapy and Body Mass Index on Cancer-Related Fatigue in Colon Cancer Patients: A PROFILES-Registry Study. Cancer Medicine 14:e70536, doi: 10.1002/cam4.70536.
Vink K, Brouwers TMJ, Beckers L, Smit D, Vos M, Guichelaar T, Bonten TN, Kervezee L, van Baarle D, Wallinga J (2025): The Chrono-Vax trial protocol: The effect of the time of day of influenza vaccination on immune responses in adults aged 60–85 years. Contemporary Clinical Trials 156: 108040, doi: 10.1016/j.cct.2025.108040
2024
Hiemstra FW, Stenvers D, Kalsbeek A, de Jonge E, van Westerloo D, Kervezee L (2024): Daily variation in blood glucose levels during continuous enteral nutrition in patients on the Intensive Care Unit: a retrospective observational study. eBioMedicine 104: 105169, doi: 10.1016/j.ebiom.2024.105169
Kervezee L, Dashti HS, Pilz LK, Skarke C, Ruben MD (2024): Using Routinely Collected Health Data for Circadian Medicine: Opportunities and Challenges. PLOS Digital Health 3(5): e0000511, doi: 10.1371/journal.pdig.0000511
Spitschan M, Kervezee L, Lok R, McGlashan E, Najjar RP (2024): How stepping out helped us tune in: finding space and time to think as an early career researcher. NPJ Biol Timing Sleep 1(1): 9, doi: 10.1038/s44323-024-00010-4
Buijink MR, Weeghel M, Harms A, Murli D, Meijer JH, Hankemeier T, Michel S, Kervezee L (2024): Loss of temporal coherence in the circadian metabolome across multiple tissues during aging in mice. European Journal of Neuroscience, doi: 10.1111/ejn.16428
Van der Hoeven AE, Bijlenga D, van der Hoeven E, Schinkelshoek MS, Hiemstra FW, Kervezee L, van Westerloo D, Fronczek R, Lammers GJ (2024): Sleep in the intensive and intermediate care units: Exploring related factors of delirium, benzodiazepine use and mortality. Intensive & Critical Care Nursing 81: 103603. doi: 10.1016/j.iccn.2023.103603
Spitschan M*, Kervezee L*, Lok R*, McGlashan E*, Najjar RP* (2024): Brighter future for light therapy: Harmonizing the reporting of light interventions. BMJ Mental Health, doi: 10.1136/bmjment-2024-301060 *Shared corresponding authorship
2023
Luetz A, Spies C, Kervezee L (2023): It’s about time: circadian medicine in the intensive care unit. Intensive Care Medicine. doi: 10.1007/s00134-023-07297-0
Albalak G, Noordam R, van der Elst M, Kervezee L, Exadaktylos V, van Bodegom D, van Heemst D (2024): Older adults exercising ON TIME: protocol for a randomized cross-over study to assess the effect of physical activity timing on insomnia severity. Trials 25(1): 523, doi: 10.1186/s13063-024-08310-7
Spitschan M*, Kervezee L*, Lok R*, McGlashan E*, Najjar RP* on behalf of the ENLIGHT Consortium (2023): ENLIGHT Consensus Checklist and Guidelines for reporting laboratory studies on the non-visual effects of light in humans. eBioMedicine. In press. Preprint on bioRxiv. doi: 10.1101/2023.03.17.532785v1 *shared corresponding authorship
Michel S and Kervezee L (2023): One seasonal clock fits all? Journal of Comparative Physiology A. doi: 10.1007/s00359-023-01680-4
Van der Linden I, Hazelhoff EM, de Groot ER, Vijlbrief DC, Schlangen LJM, de Kort YAW, Vermeulen MJ, van Gilst D, Dudink J, Kervezee L (2023): Characterizing light-dark cycles in the Neonatal Intensive Care Unit: a retrospective observational study. Frontiers in Physiology 14. doi: 10.3389/fphys.2023.1217660
Kosmadopoulos A, Boudreau P, Kervezee L, Boivin DB (2023): Circadian adaptation of melatonin and cortisol in police officers working rotating shifts. Journal of Biological Rhythms. in press. doi: 10.1177/07487304231196280
Van Gilst D, Puchkina AV, Roelants JA, Kervezee L, Dudink J, Reiss I, van der Horst G, Vermeulen MJ, Chaves I (2023): Effects of the neonatal intensive care environment on circadian health and development of preterm infants. Frontiers in Physiology 14. doi: 10.3389/fphys.2023.1243162
2022 & earlier
Boivin DB, Caetano G, Gonzales-Aste F, Kervezee L, Boudreau P (2022): Exploratory study of the effects of sex and hormonal contraceptives on alertness, fatigue and sleepiness of police officers on rotating shifts. Sleep Advances. doi: 10.1093/sleepadvances/zpac049
Kervezee L, Koshy A, Cermakian N, Boivin DB (2023): The Effect of Night Shifts on 24-h Rhythms in the Urinary Metabolome of Police Officers on a Rotating Work Schedule. Journal of Biological Rhythms. doi: 10.1177/07487304221132088
Wiersema J, Kamphuis A, Rohling JHT, Kervezee L, Akintola A, Jansen S, Eline Slagboom PE, van Heemst D, van der Spoel E (2022): The association between continuous ambulatory heart rate, heart rate variability, and 24-h rhythms of heart rate with familial longevity and aging. Aging. doi: 10.18632/aging.204219
Hazelhoff EM, Dudink J, Meijer JH, Kervezee L (2021): Beginning to see the light: Lessons learned from the development of the circadian system for optimizing light conditions in the Neonatal Intensive Care Unit. Frontiers in Neuroscience doi: 10.3389/fnins.2021.634034
Kervezee L, Gonzales-Aste F, Boudreau P, Boivin DB (2021): The relationship between chronotype and sleep behavior during rotating shift work: a field study. SLEEP doi: 10.1093/sleep/zsaa225
Visser S, van Diemen W, Kervezee L, van den Hoogen A, Verschuren O, Pillen S, Benders M, Dudink J (2021): The Relationship Between Preterm Birth and Sleep in Children At School Age: A Systematic Review. Sleep Medicine Reviews. doi: 10.1016/j.smrv.2021.101447
Kosmadopoulos A, Kervezee L, Boudreau P, Gonzales-Aste F, Vujovic N, Scheer FAJL, Boivin DB (2020): Effects of shift work on the eating behavior of police officers on patrol. Nutrients 12(4): 999. doi: 10.3390/nu12040999
Kervezee L, Kosmadopoulos A, Boivin DB (2020): Metabolic and cardiovascular impacts of shift work: the role of circadian disruption and sleep disturbances. Eur J Neurosci 51:396–412. doi: 10.1111/ejn.14216
Nobis C, Dubeau-Laramée G, Kervezee L, Maurice-De Sousa D, Labrecque N, Cermakian N (2019): The circadian clock of CD8 T cells modulates their early response to vaccination and the rhythmicity of related signaling pathways. Proc. Natl. Acad. Sci. U.S.A. 116 (40): 20077-20086.doi: 10.1073/pnas.1905080116
Kervezee L, Cermakian N, Boivin DB (2019): Individual metabolomic signatures of circadian misalignment during simulated night shifts in humans. PLOS Biology 17(6): e3000303. doi: 10.1371/journal.pbio.3000303
Kervezee L, Cuesta M, Cermakian N, Boivin DB (2019): The phase-shifting effect of bright light exposure on circadian rhythmicity in the human transcriptome. Journal of Biological Rhythms 34: 84-97 doi: 10.1177/0748730418821776
Kervezee L, Cuesta M, Cermakian N, Boivin DB (2018): Simulated night shift work induces circadian misalignment of the human peripheral blood mononuclear cell transcriptome. Proc. Natl. Acad. Sci. U.S.A. 115(21): 5540-5545. doi: 10.1073/pnas.1720719115
Kervezee L, Shechter A, Boivin DB (2018): Impact of shift work on the circadian timing system and health in women. Sleep Medicine Clinics 13(3): 295-306. doi: 10.1016/j.jsmc.2018.04.003
Kervezee L, Hartman R, van den Berg DJ, Meijer JH, de Lange ECM (2017): Daily variation in the pharmacokinetics and brain distribution of morphine. European Journal of Pharmaceutical Sciences 109S: S132-S139. doi: 10.1016/j.ejps.2017.05.048
Kervezee L, Burggraaf J (2017): Response to “Time of the day and magnitude of the effect of a drug on the QTc interval”. CPT Pharmacometrics Syst. Pharmacol. 6: 284. doi: 10.1002/psp4.12188
Kervezee L, Gotta, V, Stevens J, Birkhoff W, Kamerling IMC, Danhof M, Meijer JH, Burggraaf J (2016): Levofloxacin-induced QTc prolongation depends on the time of drug administration. CPT Pharmacometrics Syst. Pharmacol. 5: 466-474. doi: 10.1002/psp4.12085
Kervezee L, Stevens J, Birkhoff W, Kamerling IMC, de Boer T, Dröge M, Meijer JH, and Burggraaf J (2016): Identifying 24‐hour variation in the pharmacokinetics of levofloxacin: a population pharmacokinetic approach. British Journal of Clinical Pharmacology 81: 256–268. doi: 10.1111/bcp.12783
Van Rongen A*, Kervezee L*, Brill MJE, van Meir H, den Hartigh J, Guchelaar HJ, Meijer JH, Burggraaf J, and van Oosterhout F (2015): Population pharmacokinetic model characterizing 24‐hour variation in the pharmacokinetics of oral and intravenous midazolam in healthy volunteers. CPT: Pharmacometrics & Systems Pharmacology 4: 454-464. doi: 10.1002/psp4.12007 *Shared first authors
Kervezee L, Hartman R, van den Berg DJ, Shimizu S, Emoto-Yamamoto Y, Meijer JH and de Lange ECM (2014): Diurnal variation in P-glycoprotein mediated transport and cerebrospinal fluid turnover in the central nervous system. AAPS Journal 16:1029-37. doi: 10.1208/s12248-014-9625-4
Circadian Medicine Group 